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RESEARCH PAPERS

We have been studying our Lab4 probiotic consortia for more than 25 years and have built a large library of research. The published papers are covering areas as diverse as IBS, athletic performance, antibiotics, allergy in babies and children, immunity and weight loss.

Antibiotics and Gut Microbiome Study

John D et al 2024. A double-blind, randomized, placebo-controlled study assessing the impact of probiotic supplementation on antibiotic induced changes in the gut microbiome. Front. Microbiomes 3:1359580.
2024

The IBS in Women Study

Mullish BH et al. 2024. A double-blind, randomized, placebo-controlled study assessing the impact of probiotic supplementation on the symptoms of irritable bowel syndrome in females. Neurogastroenterol Motil. 2024 Jan 29:e14751
2024

The ProChild & ProChild-2 Studies: Preschool children

Paduchova Z et al 2024. The impact of probiotics and vitamin C on the prevention of upper respiratory tract symptoms in two preschool children cohorts. Nutrition Research and Practice 18 (1):98-109
2024

The Probiotics and Healthy Adult Study

Mullish BH et al 2023. The gastrointestinal status of healthy adults: a post hoc 2 assessment of the impact of three distinct probiotics. Beneficial Microbes, 1-14
2023

The ProChild-2 Study: Antibiotic prescriptions

Garaiova I et al 2023. Probiotics with low dose vitamin C reduce antibiotic prescriptions in children: A secondary analysis of a multicentre randomised double-blind placebo-controlled trial. Journal of Functional Foods 106: 105625
2023

The ProChild-2 study

Garaiova I et al 2021. Probiotics with vitamin C for the prevention of upper respiratory tract symptoms in children aged 3-10 years: randomised controlled trial. Beneficial Microbes 12 (5): 431-440.
2021

The PROBE study

Michael DR et al. 2021. Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults. Scientific Reports 11, 5.
2021

The Promagen Study – Viral pandemic link

Mullish BH et al. 2021
Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics? Gut Microbes 13(1): e1900997
2021

The Promagen Study: Weight loss and Cholesterol

Michael DR et al 2020. A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being.
Scientific Reports 2020; 10(1): 4183
2020

The Promagen Study – URTI symptoms

Michael DR et al. 2020
A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being.
Scientific Reports 10(1): 4183
2020

The Promagen Study – Quality of life

Michael DR et al. 2020
A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being.
Scientific Reports 10(1): 4183
2020

The Cycling Endurance Study

Pugh JN et al 2020. Probiotic supplementation increases carbohydrate metabolism in trained male cyclists: a randomised, double-blind, placebo-controlled crossover trial. American Journal of Physiology, Endocrinology and Metabolism 318 (4): E504-E513
2020

The Marathon Endurance Study

Pugh JN et al 2019. Four weeks of probiotic supplementation reduces GI symptoms during a marathon race.
European Journal of Applied Physiology
2019

Lab4 Consortia and Neuroprotection Study

Michael DR et al. 2019 In vitro neuroprotective activities of two distinct probiotic consortia. Beneficial Microbes 10 (4): 437-447
2019

The Ultra Marathon Endurance Study

Marshall H, Chrismas BC, Suckling CA, Roberts JD, Foster J, Taylor L. Chronic probiotic supplementation with or without glutamine does not influence the eHsp72 response to a multi-day ultra-endurance exercise event. Appl Physiol Nutr Metab 2017; 42(8): 876-883.
2017

Lab4 and Memory Improvement Study

O’Hagan C, Li JV, Marchesi JR, Plummer S, Garaiova I, Good MA. Long-term multi-species Lactobacillus and Bifidobacterium dietary supplement enhances memory and changes regional brain metabolites in middle-aged rats. Neurobiology of Learning and Memory 2017; 144: 36-47
2017

Lab4 and Cholesterol Study

Michael DR et al. 2017 The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice. Scientific Reports 7:2883
2017

Lab4P and Cholesterol Study

Michael DR et al. The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice. Scientific Reports 2017: 7:2883
2017

The Hertfordshire Study

Roberts JD et al 2016. An Exploratory Investigation of Endotoxin Levels in Novice Long Distance Triathletes, and the Effects of a Multi-Strain Probiotic/Prebiotic, Antioxidant Intervention.
Nutrients 2016; 8:733.
2016

Lactobacillus plantarum CUL66 and Cholesterol study

Michael DR et al. 2016 Lactobacillus plantarum CUL66 can impact cholesterol homeostasis in Caco-2 enterocytes. Beneficial Microbes 7(3):443-51
2016

The ProChild study

Garaiova I et al 2015. Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study.
European Journal of Clinical Nutrition 69: 373-379.
2015

The Keele Study

Owen L et al 2014. A double-blind, placebo-controlled, randomised pilot trial examining the effects of probiotic administration on mood and cognitive function.
Proceedings of the Nutrition Society 2014, 73 (OCE1): E29
2014

Running to exhaustion study

Shing CM et al 2014. Effects of probiotics supplementation on gastrointestinal permeability, inflammation and exercise performance in the heat. European Journal of Applied Physiology 114: 93-103
2014

The Swansea Baby Trial

Allen SJ et al 2014. Probiotics in the prevention of eczema: a randomised controlled trial.
Archives of Disease in Childhood 99(11): 1014–1019
2014

The Adult Immune Response Study

Hepburn NJ et al 2013. Probiotic supplement consumption alters cytokine production from peripheral blood mononuclear cells: a preliminary study using healthy individuals.
Beneficial Microbes, 4(4): 313-17
2013

The Cambridge IBS Study

Plummer S et al 2013. Effects of probiotics on the caecal and faecal microbiota of Irritable Bowel Syndrome patients receiving antibiotics: a pilot study.
Short Communication. ENGIHR, Valencia, Spain, 18-20th September 2013, pg183-6
2013

The Swansea Safety In Newborns

Allen SJ et al 2010. Dietary supplementation with Lactobacilli and Bifidobacteria is well tolerated and not associated with adverse events during late pregnancy and early infancy.
Journal of Nutrition 140:483-488
2010

The Cardiff Tracking Study

Mahenthiralingam E et al 2009. Use of colony-based bacterial strain typing for tracking the fate of Lactobacillus strains during human consumption.
BMC Microbiology, 9:251
2009

The Sheffield IBS Trial

Williams EA et al 2008. Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study.
Alimentary Pharmacology & Therapeutics, 29: 97-103
2008

The Cambridge Probiotic/ Antibiotic Trial 1

Madden JAJ et al 2005. Effects of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: A double-blind, placebo-controlled pilot study. 
International Immunopharmacology 5:1091-1097
2005

The Cambridge Probiotic/ Antibiotic Trial 2

Plummer S et al 2005. Effects of probiotics on the composition of the intestinal microbiota following antibiotic therapy. 
International Journal of Antimicrobial Agents 26:69-74
2005

The Cambridge Clostridium difficile Study

Plummer S et al 2004. Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of Clostridium difficile diarrhoea. International Microbiology, 7:59-62
2004
WORK WITH US

Lab4 by Cultech offers a full range of products and services, from bulk powders to contract manufacturing to individual product manufacture as private label or using our ProVen Biotics brand.

  • Baglan Industrial Park,
    Unit 2 Christchurch Road,
    Port Talbot SA12 7BZ
  • 01639 825100
  • [email protected]
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