The Sheffield IBS Trial

Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled probiotics and IBS study

SUMMARY

This double-blind, placebo-controlled trial investigated the effect of Lab4 multistrain probiotic preparation on the symptoms of irritable bowel syndrome (IBS).
The significant reduction in total IBS symptoms was observed in IBS sufferers taking the Lab4 probiotics for 8 weeks.
Satisfaction with bowel habit and quality of life were significantly improved with Lab4 probiotics.
Continued Lab4 probiotic supplementation appears to be necessary to sustain the benefits.

Aim

This randomised, double-blind, placebo controlled study investigated the effect of supplementation with Lab4 probiotics on the symptoms of IBS.

Method

Results

  • The participants taking the Lab4 probiotics (Group 2) showed significant reduction in Total IBS symptoms compared to placebo (Group 1, *P<0.05).
  • The reductions in days with pain and bloating were achieved with Group 2.
  • Satisfaction with bowel habit and quality of life were significantly improved in Group 2 (reduction in the symptom severity scores).
  • Improvement in IBS symptoms diminished quickly when the Lab4 probiotic supplementation was discontinued (week 10, 2 weeks after the intervention).

Conclusion

The Lab4 probiotics significantly reduced total symptoms and improved quality of life in diagnosed IBS sufferers. Continued supplementation was considered necessary to sustain this improvement.
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