Supported by more than 15 clinical trials
Identified and commercialised in 1998, the Lab4 probiotics consortium contains four proprietary bacteria strains – Lactobacillus acidophilus CUL60, Lactobacillus acidophilus CUL21, Bifidobacterium animalis subsp. lactis CUL34 and Bifidobacterium bifidum CUL20.
The Lab4 probiotics blend is supported by more than 15 clinical trials and a number of in vitro and in vivo studies across a wide range of conditions at doses ranging from 12.5 billion CFUs to 50 billion CFUs per day. The conditions studied to date include C. difficile, using probiotics alongside antibiotics, irritable bowel syndrome (IBS), immunity, upper respiratory tract infection (URTI), mood and performance.
2024
The IBS in Women Study
A double-blind, randomized, placebo-controlled study assessing the impact of probiotic supplementation on the symptoms of irritable bowel syndrome in females
2024
The ProChild & ProChild-2 Studies: Preschool children
The impact of probiotics and vitamin C on the prevention of upper respiratory tract symptoms in two preschool children cohorts
2023
The ProChild-2 Study: Antibiotic prescriptions
Probiotics with low dose vitamin C reduce antibiotic prescriptions in children: A secondary analysis of a multicentre randomised double-blind placebo-controlled trial
2023
The Probiotics and Healthy Adult Study
The gastrointestinal status of healthy adults: a post hoc assessment of the impact of three distinct probiotics
2021
The ProChild-2 Study
Probiotics with vitamin C for the prevention of upper respiratory tract symptoms in children aged 3-10 years: a randomised controlled trial
2020
The Cycling Endurance Study
Probiotic supplementation increases carbohydrate metabolism in trained male cyclists: a randomised, double-blind, placebo-controlled cross-over trial
2019
Lab4 Consortia and Neuroprotection
In vitro neuroprotective activities of two distinct probiotic consortia
2019
The Marathon Endurance Study
Four weeks of probiotic supplementation reduces GI symptoms during a marathon race
2017
Lab4 and Cholesterol Study
The anti-cholesterolaemic effect of a consortium of probiotics: an acute study in C57BL/6J mice (Part 1)
2017
Lab4 and Memory Improvement Study
Long-term multi-species Lactobacillus and Bifidobacterium dietary supplement enhances memory and changes regional brain metabolites in middle-aged rats
2016
The Hertfordshire Study
An exploratory investigation of endotoxin levels in novice long distance triathletes, and the effects of a multi-strain probiotic/prebiotic/antioxidant intervention
2015
The ProChild Study
Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool; a randomised controlled pilot study
2014
Running to Exhaustion Study
Effects of probiotics supplementation on gastrointestinal permeability, inflammation and exercise performance in the heat
2014
The Keele Study
A double-blind, placebo-controlled, randomised pilot trial examining the effects of probiotic administration on mood and cognitive function
2013
The Cambridge IBS Study
Effects of probiotics on the caecal and faecal microbiota of irritable bowel syndrome patients receiving antibiotics: a pilot study
2013
The Adult Immune Response Study
Probiotic supplement consumption alters cytokine production from peripheral blood mononuclear cells: a preliminary study using healthy individuals
2009
The Cardiff Tracking Study
Use of colony-based bacterial strain typing for tracking the fate of Lactobacillus strains during human consumption
2008
The Sheffield IBS Trial
Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study
2005
The Cambridge Probiotic/Antibiotic Trial 2
Effects of probiotics on the composition of the intestinal microbiota following antibiotic therapy
2005
The Cambridge Probiotic/Antibiotic Trial 1
Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: a double-blind, placebo-controlled pilot study
2004
The Cambridge Clostridium difficile Study
Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhoea
