Supported by 14 clinical trials
Identified and isolated in 1999 and commericalised in 2004, the Lab4 probiotics consortium contains four proprietary bacteria strains – Lactobacillus acidophilus (CUL60), Lactobacillus acidophilus (CUL21), Bifidobacterium animalis subsp. lactis (CUL34) and Bifidobacterium bifidum (CUL20).
The Lab4 probiotics blend is supported by 14 clinical trials and a number of in vitro and in vivo studies across a wide range of conditions at doses ranging from 12.5 billion CFUs to 50 billion CFUs per day. The conditions studied to date include C. difficile, using probiotics alongside antibiotics, irritable bowel syndrome (IBS), immunity, upper respiratory tract infection (URTI), mood and performance.
2004
The Cambridge Clostridium difficile Study
Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhoea
2005
The Cambridge Probiotic/Antibiotic Trial 1
Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: a double-blind, placebo-controlled pilot study
2005
The Cambridge Probiotic/Antibiotic Trial 2
Effects of probiotics on the composition of the intestinal microbiota following antibiotic therapy
2008
The Sheffield IBS Trial
Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study
2009
The Cardiff Tracking Study
Use of colony-based bacterial strain typing for tracking the fate of Lactobacillus strains during human consumption
2013
The Adult Immune Response Study
Probiotic supplement consumption alters cytokine production from peripheral blood mononuclear cells: a preliminary study using healthy individuals
2013
The Cambridge IBS Study
Effects of probiotics on the caecal and faecal microbiota of irritable bowel syndrome patients receiving antibiotics: a pilot study
2014
The Keele Study
A double-blind, placebo-controlled, randomised pilot trial examining the effects of probiotic administration on mood and cognitive function
2014
Running to Exhaustion Study
Effects of probiotics supplementation on gastrointestinal permeability, inflammation and exercise performance in the heat
2015
The ProChild Study
Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool; a randomised controlled pilot study
2016
The Hertfordshire Study
An exploratory investigation of endotoxin levels in novice long distance triathletes, and the effects of a multi-strain probiotic/prebiotic/antioxidant intervention
2017
Lab4 and Cholesterol Study
The anti-cholesterolaemic effect of a consortium of probiotics: an acute study in C57BL/6J mice (Part 1)
2017
Lab4 and Memory Improvement Study
Long-term multi-species Lactobacillus and Bifidobacterium dietary supplement enhances memory and changes regional brain metabolites in middle-aged rats
2019
Lab4 Consortia and Neuroprotection
In vitro neuroprotective activities of two distinct probiotic consortia
2019
The Marathon Endurance Study
Four weeks of probiotic supplementation reduces GI symptoms during a marathon race
2020
The Cycling Endurance Study
Probiotic supplementation increases carbohydrate metabolism in trained male cyclists: a randomised, double-blind, placebo-controlled cross-over trial
2021
The ProChild-2 Study
Probiotics with vitamin C for the prevention of upper respiratory tract symptoms in children aged 3-10 years: a randomised controlled trial
