Our Research

Randomised, double-blind, placebo-controlled study that showed supplementation with Lab4 Probiotics can reduce the incidence of antibiotic associated Clostridium difficile diarrhoea in hospitalised patients.

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Randomised, double-blind, placebo-controlled study showed that Lab4 Probiotics supplementation alongside antibiotic therapy reduced the overgrowth of undesirable and potentially harmful bacteria both during and following antibiotic therapy.

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Randomised, double-blind, placebo-controlled study showed that Lab4 Probiotics supplementation alongside antibiotic therapy reduces the extent of gut microbiota disruption AND reduces the level of antibiotic resistance in the ‘re-growth’ microbiota.

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Randomised, double-blind, placebo-controlled study that showed Lab4 Probiotics significantly reduced total symptoms and improved quality of life in diagnosed IBS sufferers. Continued supplementation was considered necessary to sustain this improvement.

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This study used the colony fingerprint technique (RAPD) to track probiotics Lactobacillus acidophilus CUL21 (from Lab4) and Lactobacillus salivarius CUL61 (from Lab4B) and showed that they remained viable and can be ‘tracked’ through the gut passage during probiotic consumption by healthy volunteers.

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This study confirms that the use of Lab4B Probiotics is perfectly safe for mums-to-be and their healthy newborn babies.

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This study showed that supplementation with Lab4 Probiotics prior to and alongside antibiotics may provide protection against overgrowth by yeasts in IBS sufferers.

This study examined the effect of a 12-week Lab4 Probiotics and fructooligosaccharide (FOS, prebiotic fibre) supplementation on ex-vivo pro-inflammatory and anti-inflammatory cytokine production by peripheral blood mononuclear cells extracted from healthy volunteers, showing potential immunomodulatory benefits.

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This large randomised, double-blind, placebo-controlled study showed that Lactobacilli and Bifidobacteria administered to pregnant women and infants aged 0-6 months prevented atopic sensitisation and atopic eczema.

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This randomised, double-blind, placebo-controlled study showed the benefit of Lab4 Probiotics for cognitive function in healthy adults, showing improvements in ‘trait anxiety and ‘continuity of attention’.

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This randomised, double-blind, placebo-controlled cross-over study showed that four weeks of Lab4-based multi-strain probiotic supplementation significantly increased running time to exhaustion in hot environmental conditions.

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This randomised, double-blind, placebo-controlled study showed that Lab4 Probiotics in combination with vitamin C significantly reduced the incidence and duration of both coughs and colds, and absenteeism from school.

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This randomised, double-blind, placebo-controlled study showed that Lab4 Probiotics with fibre alone or in combination with antioxidants protect athletes from gut disturbances during endurance training and improve their race finishing times.

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This study showed that Lab4 Probiotics supplementation improved runners’ completion time during the ultra-marathon.

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This randomised, double-blind, placebo-controlled study showed that supplementation with Lab4 Probiotics protects endurance runners from gut disturbances during a marathon race and may help to maintain running pace during the latter stages of racing.

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This randomised, double-blind, placebo-controlled study showed that supplementation of overweight and obese adults with Lab4P Probiotics for 6 months resulted in a significant reduction in body weight in the participants with no diet or lifestyle restrictions. In addition, the incidence of URTI symptoms decreased significantly and the reported Quality of Life improved in response to the probiotics.

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This randomised, couple-blind, placebo-controlled endurance study showed that supplementation with Lab4 Probiotics increases total carbohydrate oxidation during endurance cycling, whilst fat oxidation is reduced.

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This randomised, double-blind placebo-controlled study showed that supplementation with Lab4P Probiotics for nine months resulted in a significant reduction in body weight in overweight adults aged 45-65 without any lifestyle restrictions. 40% of participants reached the desirable annual 5% weight loss shown to be beneficial for health and wellbeing. The findings of this second study with Lab4P Probiotics support the outcomes of the previous Promagen study.

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This second randomised, double-blind, placebo-controlled study undertaken over six months with pre-school and school-age children, showed that Lab4 Probiotics in combination with low dose vitamin C reduced the incidence of coughing and sore throats, as well as absence from school and antibiotic use. To our knowledge, this is the first time two probiotic studies (ProChild and ProChild-2) with the same intervention for the same duration showed a beneficial effect in the management of URTIs in children attending school.

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This further analysis of the Promagen Study investigated the impact of Lab4P Probiotics on the occurrence of specific upper respiratory tract infections (URTIs) and their relationship with age, BMI and gut microbiota diversity. It showed that supplementation of overweight and obese adults with Lab4P Probiotics for six months resulted in a significant reduction in the incidence of specific URTI symptoms, with greatest benefit in individuals aged 45 years and over and/or with BMI over 30. Lab4P Probiotics demonstrated a protective role in preventing changes in gut microbiota composition in the older participants who developed URTI symptoms.

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This randomised, double-blind, placebo-controlled study showed that Lab4 Probiotics supplementation can lessen the significant change in the metabolome (serum metabolites) induced by running a marathon.

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This secondary analysis of the multi-centre randomised, double-blind, placebo-controlled ProChild-2 study showed that a combination of Lab4 Probiotics and low dose vitamin C presents a promising and cost-effective approach to reducing the need for antibiotic prescriptions in children.

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This post hoc analysis of a double-blind, randomised, placebo-controlled trial showed that healthy adults can benefit from daily probiotic intake and Lab4 Probiotics showed the most beneficial effects on gastrointestinal symptoms and bowel habits.

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This pooled analysis of data from two studies (ProChild and ProChild-2) confirmed the beneficial effects of Lab4 Probiotics with low dose vitamin C on preventing cough and cold symptoms and reducing absenteeism, GP visits and antibiotic usage among preschool children.

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This double-blind, randomised, placebo-controlled study confirmed the beneficial effects of Lab4 Probiotics on IBS symptoms in women aged 18 to 40 years. It is the second study to confirm the benefits of Lab4 Probiotics supplementation in the management of IBS.

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This double-blind, randomised, placebo-controlled study showed that the combination of Lab4 Probiotics and Saccharomyces boulardii alongside antibiotic treatment may help to reduce antibiotic-associated disturbances by protecting against loss of microbial diversity and lowering antibiotic resistance in the re-growth microbiota.

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