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Our Research

Lab4 Probiotics have to date been subject to more than 35 probiotic clinical trials supported by continuous in vitro and in vivo studies. These studies cover a broader range of conditions than any other multi-strain probiotic consortia* in the world, including IBS, immunity, allergy, athletic performance, cognitive function, antibiotics and weight loss. 

Lab4 Probiotics Research 

More than 100 papers/PhDs published on Lab4 and/or the microbiome 

35+

Clinical Trials

10+

PhD Programmes

8+

In Vivo Publications

20+

In Vitro Publications

Research at a Glance

 

Lab4

Lab4B

Lab4P

Lab4S

Safety Assessment

 

 

Gut Health

 

 

 

 

IBS

 

 

 

Intestinal permeability

 

 

 

Gut symptoms/Bowel habits

 

 

Gut microbiota preservation

 

 

Antibiotics

 

 

 

 

Antibiotic prescription

 

 

 

Antibiotic resistance

 

 

Allergy

 

 

 

 

Atopic eczema

 

 

 

Atopic sensitisation

 

 

 

Immune Health

 

 

 

 

URTI

 

 

Immune response

 

 

 

Metabolic Health

 

 

 

 

Weight management

 

 

 

sdLDL cholesterol

 

 

 

Mental Health

 

 

 

 

Anxiety, depression in IBS

 

 

 

Anxiety/Cognitive function

 

 

 

Quality of Life

 

 

Athletic Performance

 

 

 

 

Race time

 

 

 

Energy utilisation

 

 

 

Metabolic perturbation

 

 

 

Timeline of Publications

Lab4

1998

Lab4 Probiotic consortium developed & introduced commercially

1999

First Clinical Trial using Lab4 conducted

2004

The Cambridge Clostridium difficile Study

2005

The Cambridge Probiotic/Antibiotic Trial 1

The Cambridge Probiotic/Antibiotic Trial 2

2008

The Sheffield IBS Trial

2009

The Cardiff Tracking Study

2010

The Swansea ‘Safety in Newborns’

2013

The Cambridge IBS Study

The Adult Immune Response Study

2014

The Swansea Baby Study

The Keele Study

Running to Exhaustion Study

2015

The ProChild Study

2016

The Hertfordshire Study

2017

The Ultra Marathon Endurance Study

2019

The Marathon Endurance Study

2020

The Promagen Study

The Cycling Endurance Study

2021

The Probe Study

The ProChild-2 Study

The Promagen Study: Viral Pandemic Link?

The Marathon Endurance Study: Metabolites

2023

The ProChild-2 Study: Antibiotic Prescriptions

The Probiotics & Healthy Adult Study

2024

The ProChild & ProChild-2 Studies: Preschool children

The IBS in Women Study

Antibiotics and Gut Microbiome Study

For further information on our research, please contact us at info@lab4probiotics.co.uk 

*more than two probiotic strains