The ProChild-2 Study: Antibiotic prescriptions

Probiotics with low dose vitamin C reduce antibiotic prescriptions in children: A secondary analysis of a multicentre randomised double-blind placebo-controlled trial


  • In our second long-term double-blind, placebo-controlled study, we examined the effects of the Lab4 probiotics with vitamin C combination on antibiotic prescribing in children.
  • The incidence of oral antibiotic prescriptions was significantly reduced by 48%.
  • Children taking the Lab4 probiotic/vitamin C combination had a 40% lower risk of being prescribed oral antibiotics.


During the randomised, double-blind, placebo-controlled study in children aged 3 to 10 years, we investigated the effects of the Lab4 probiotic with low dose of vitamin C combination on symptoms related to upper respiratory tract infections. As part of this study, we also examined the incidence of antibiotic prescriptions among the participants.



Oral antibiotic prescription

  • 48% significant reduction in the incidence of oral antibiotic prescriptions in Group 2 compared to Group 1 (*P=0.0079).
  • 25.6% children in Group 2 were prescribed oral antibiotics compared to 42.3% children in Group 1 (40% significant reduction, *P=0.0239).

Paediatric physician’s visits

  • The number of unscheduled visits to the GP was reduced by 18% with the use of Lab4 probiotic and vitamin C (Group 2) compared to Group 1 (#P=0.0587). 


The combination of Lab4 probiotics and vitamin C presents a promising and cost-effective approach to reducing the need for antibiotic prescriptions.

Study links


The ProChild-2 Study

Probiotics with vitamin C for the prevention of upper respiratory tract symptoms in children aged 3-10 years: a randomised controlled trial

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