The PROBE Study
This randomised, double-blind, placebo controlled study aimed to assess the effect of 9-months supplementation with Lab4P probiotics on body weight in overweight adults.
- Lab4P probiotic supplementation (Group 2) resulted in significant weight loss compared to Group 1 (****P<0001, Fig. 1)
A difference of -2.11kg at 3 months (2.51% reduction)
A difference of -1.88kg at 6 months (2.19% reduction)
A difference of -3.16kg at 9 months (3.76% reduction)
- By 9 months, 71% participants taking Lab4P probiotics (Group 2) had achieved 3% substantial weight loss compared to 17% participants in Group 1.
- 40% of participants in Group 2 reached the clinically meaningful weight loss (defined as 5% weight loss over a 6-12-month period) compared to 3% participants in Group 1. Consistent weight loss in Group 2 was observed even during the indulgent Christmas period (during months 6 to 9), whereas Group 1 gained weight during this period
- A significant difference in BMI between groups at each time point were observed with a significant 3.73% reduction in BMI in Group 2 compared to Group 1 at 9 months (Fig. 2)
- At 9 months, 6 participants from Group 2 moved from overweight BMI status to healthy BMI status compared with 2 participants in Group 1
Waist and Hip Circumference
- A significant reduction in waist circumference (WC) at each time point was observed in Group 2 compared to Group 1 with a 2.48% reduction at 9 months (-2.58 cm, Fig. 3).
- Similarly, significant changes in hip circumference (HC) were found over the study period. The supplementation with Lab4P probiotics (Group 2) resulted in a significant 2.36% reduction in HC compared to Group 1 at 9 months (-2.66 cm, Fig. 4).
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