The PROMAGEN Study: Weight loss and Cholesterol
A randomised controlled study shows supplementation of overweight and obese adults with Lactobacilli and Bifidobacteria reduces bodyweight and improves wellbeing
SUMMARY
An exploratory, block-randomised, parallel, double-blind, single-centre, placebo-controlled superiority study with 220 overweight and obese adults with BMI 25-34.9. The probiotic group (110) took 50 billion Lab4P probiotics every day for six months and the placebo group (110) took an identical-looking placebo.
Lab4P probiotic supplementation significantly reduced bodyweight by 1.5% in the overweight and obese adults with no changes to diet or lifestyle.
A greater reduction in bodyweight loss was observed in the overweight adults (1.9%), adults over 50 years old (2%) and adults with high cholesterol levels (2.5%).
The levels of atherogenic small dense LDL cholesterol were significantly reduced in hypercholesterolaemic overweight and obese adults supplemented with Lab4P probiotics.
Aim
This randomised, double-blind, placebo-controlled study aimed to assess the effect of 6-months’ supplementation with the Lab4P probiotic on body weight and wellbeing in healthy overweight and obese individuals.
Method
![](https://lab4probiotics.co.uk/wp-content/uploads/2021/02/promagen-study-1-method-update2.png)
Results
Body weight, BMI and Waist Circumference
![](https://lab4probiotics.co.uk/wp-content/uploads/2021/02/promagen-study-1.2.png)
Lab4P probiotic supplementation (Group 2) resulted in significant weight loss compared to Group 1 (Fig. 1):
– A difference of -1.3kg in the total population (****P< 0.0001)
– A difference of -1.4kg in the overweight participants (****P< 0.0001)
– A difference of -1.76kg in the over 50 year olds (***P< 0.001)
– A difference of -2.1kg in the hypercholesteraemic participants (****P< 0.0001)
Significant reductions in BMI, waist circumference and waist-to-height ratio were also observed in each of the above populations.
Greater rates of weight loss were observed in the overweight participants compared to the obese (1.9% vs. 1.2% reduction) and in women compared to men (1.6 vs. 1.4% reduction).
Plasma Cholesterol levels in hypercholesterolaemic participants (total cholesterol > 6.2 mmol/l)
![](https://lab4probiotics.co.uk/wp-content/uploads/2021/05/promagenproagen-weight-loss-cholesterol-fig-2.png)
A significant reduction of 17.6% in the plasma levels of atherogenic small dense LDL-cholesterol (sdLDL-C) was observed in hypercholesterolaemic participants taking Lab4P probiotics (Group 2a) compared to Group 1a (*P<0.05). The plasma LDL-C levels were reduced by 6.59%.
Conclusion
Study links
2016
![](https://lab4probiotics.co.uk/wp-content/uploads/2020/10/lab4-lab4p-cholesterol-tile.png)
Lactobacillus plantarum CUL66 and Cholesterol Study
Lactobacillus plantarum CUL66 can impact cholesterol homeostasis in Caco-2 enterocytes
2016
![](https://lab4probiotics.co.uk/wp-content/uploads/2020/10/lab4-lab4p-cholesterol-tile.png)
Lactobacillus plantarum CUL66 and Cholesterol Study
Lactobacillus plantarum CUL66 can impact cholesterol homeostasis in Caco-2 enterocytes
2017
![](https://lab4probiotics.co.uk/wp-content/uploads/2020/10/lab4-p-cholesterol-tile.png)
Lab4P and Cholesterol Study
The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice (Part 2)
2020
![](https://lab4probiotics.co.uk/wp-content/uploads/2020/10/promagen-study.jpg)
The PROMAGEN Study: Viral pandemic link?
Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics?
2020
![](https://lab4probiotics.co.uk/wp-content/uploads/2020/10/promagen-study.jpg)
The PROMAGEN Study: URTI Symptoms
A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being
2020
![](https://lab4probiotics.co.uk/wp-content/uploads/2020/10/promagen-study.jpg)
The PROMAGEN Study: Quality of Life
A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being
2021
![](https://lab4probiotics.co.uk/wp-content/uploads/2021/02/Probe-study-tile.png)
The PROBE Study
Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults