The Keele Study

A double blind, placebo controlled, randomised pilot trial examining the effects of probiotic administration on mood and cognitive function

SUMMARY

A double-blind, randomised, controlled trial with 50 healthy participants using mood, stress and depression questionnaires to examine the mood and cognitive function effects of probiotic supplementation
Healthy adults supplemented with Lab4 probiotics experienced reduced anxiety in response to the anticipation of a future threat.
The ability to focus and avoid any distraction was significantly increased with Lab4 probiotics.

Aim

This randomised, double blind, placebo controlled study examined the effects of Lab4 probiotics on general feelings of anxiety, mood and cognitive function in healthy individuals.

Method

Results

‘Trait’ Anxiety

(individual’s tendency to experience anxiety in response to the anticipation of a future threat, how individuals felt over the previous 6 weeks)
Lab4 probiotics significantly decreased ‘trait’ anxiety levels compared to Group 1, where the ‘trait’ anxiety levels increased over the course of the 6 weeks supplementation (P=0.042).

‘Continuity of attention’

(ability to focus and avoid distraction)
‘Continuity of attention’ significantly increased in response to the Lab4 supplementation and decreased in Group 1 (P=0.035).

Conclusion

The study showed the benefit of Lab4 probiotics for cognitive function in healthy individuals.

Reference

Owen L, et al 2014. A double blind, placebo controlled, randomised pilot trial examining the effects of probiotic administration on mood and cognitive function. Proceedings of the Nutrition Society 2014, 73 (OCE1): E29
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