Lactobacillus plantarum CUL66 and Cholesterol Study
Lactobacillus plantarum CUL66 can impact cholesterol homeostasis in Caco-2 enterocytes
Hypercholesterolemia drives the development of cardiovascular disease, the leading cause of mortality in western society, and supplementation with probiotics that interfere with cholesterol metabolism may provide a contribution to disease prevention. Lactobacillus plantarum CUL66 (NCIMB 30280) has been assessed in vitro for its ability to impact cholesterol absorption and identified as a cholesterol lowering strain by demonstrating its ability to reduce the process of cholesterol uptake in the gut intestine.
To determine the cholesterol lowering abilities of the strain L. plantarum CUL66 (NCIMB 30280) isolated from a healthy human and to assess the molecular mechanisms of its ability to reduce cholesterol uptake in an in vitro model of the intestinal epithelium.
Bile salt hydrolase activity
Summary of Lactobacillus plantarum CUL66 Mechanism of Action
Lactobacillus plantarum CUL66 is a very promising cholesterol lowering candidate.