Infant & Child health

Probiotics and atopy prevention

Probiotics significantly reduced the risk of atopic sensitisation by 29% when administered prenatally to the pregnant mother and postnatally to infant (RR 0.71; 95% CI, 0.57 to 0.89) and the risk of food sensitization (RR 0.77; 95% CI, 0.61 to 0.98)1. The meta-analysis of 17 studies with 4755 children showed that probiotic supplementation during pregnancy

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Probiotics and acidosis in healthy children

A review of five randomised controlled trials from 2005 to 2017 with 544 healthy infants (one day to 12 months of age) showed that D-lactic acid producing probiotic bacteria and fermented infant formulas did not cause D-lactic acidosis in healthy children. The only reported cases of paediatric D-lactic acidosis were in children with short bowel

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Gut microbiome development in neonates

Various factors influence the gut microbiome development in neonates during prenatal, perinatal and postnatal periods, including maternal diet and lifestyle, mode of birth, feeding, antibiotic use and length of gestation. The reciprocal relationship between gut microbiota and gastrointestinal tract development from in utero to postnatal life is discussed in more details.   Link: View the

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Probiotics for the prevention of Clostridium difficile infection

The aim of this recent study was to find out whether the probiotic supplementation alongside antibiotic treatment will reduce the incidence of Clostridium difficile infection in adults and children. Individual data of 6851 participants from 18 published randomised controlled trials were included in the statistical analysis. 72.2% of the studies were conducted in adult hospitalised

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Probiotics for recurrent abdominal pain

The effect of dietary interventions for recurrent abdominal pain in 1453 children aged between 4 and 18 years was assessed in the Cochrane systematic review of 19 randomised controlled trials. Thirteen studies (1017 children) investigated the effect of probiotics compared to placebo, four studies (299 children) were trials of fibre-based interventions, one study (34 children)

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Probiotics for the prevention of upper respiratory tract infections

The effect and safety of probiotics in the prevention of acute upper respiratory tract infections (URTIs) in 3720 participants of all ages were assessed in the Cochrane systematic review of 12 randomised controlled trials. The results of the meta-analysis suggested that probiotics may be effective in reducing the number of participants with episodes of acute

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